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The Extent of Perfusion–F18-Fluorodeoxyglucose Positron Emission Tomography Mismatch Determines Mortality in Medically Treated Patients With Chronic Ischemic Left Ventricular Dysfunction

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2005 Italy Publisher:Elsevier BVJournal:Journal of the American College of Cardiology, volume 46, pages 1,264-1,269 (issn: 0735-1097,

Authors: DESIDERI A; CORTIGIANI L; CHRISTEN AI; COSCARELLI S; GREGORI, DARIO; ZANCO P; KOMOROVSKY R; +1 Authors

doi: 10.1016/j.jacc.2005.06.057

pmid: 16198841

handle: 11577/2443129

The Extent of Perfusion–F18-Fluorodeoxyglucose Positron Emission Tomography Mismatch Determines Mortality in Medically Treated Patients With Chronic Ischemic Left Ventricular Dysfunction

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Abstract

The purpose of this study was to assess the determinants of mortality in a large group of patients with ischemic cardiomyopathy who are treated medically and the impact of the extent of viable tissue on prognosis.Whether the presence of viability drives mortality in patients with ischemic cardiomyopathy who are treated medically and whether the extent of viability is important are issues that are currently unclear.Two hundred sixty-one patients with ischemic cardiomyopathy underwent positron emission tomography (PET) for assessment of viability. Prospective follow-up was obtained.Ninety-four patients were revascularized and 167 were not. The cardiac death rate was significantly less in the revascularized patients as compared with medically treated patients (13% vs. 24%, p 20% (HR 3.21, 95% CI 1.38 to 7.49).Medically treated patients with ischemic cardiomyopathy and large areas of viable myocardium on PET are at high risk for cardiac death.

Country

Italy

Related Organizations

University of Turin
Italy
University of Padua
Italy
Cardiovascular Research Foundation
United States
University of Turin
Italy
Cardiology Department
Switzerland

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Keywords

Male, Myocardial Ischemia, Prognosis, Ventricular Dysfunction, Left, Fluorodeoxyglucose F18, Positron-Emission Tomography, Chronic Disease, Humans, Female, Prospective Studies, Radiopharmaceuticals, Cardiology and Cardiovascular Medicine, Aged, Follow-Up Studies

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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%