M onkeypox is an infection caused by an Orthopoxvirus first identified in humans in the 1970s in Africa. Since then, there have been outbreaks in and outside Africa, the most significant having occurred in 2022 and 2023, which was declared a public health emergency by the World Health Organization and mainly affected men who have sex with men. It has resulted in more than 92,000 cases globally.1 1 This infection courses with yellow-white pseudopustules surrounded by perilesional erythema. After several days, a central umbilication appears, which becomes necrotic as it progresses in a centrifugal fashion (Figs 1 to 4). Eventually the necrotic crust covers the entire lesion until it falls off leaving residual erythema (Figs 5 and 6).2 2 Atrophic scarring can severely affect the quality of life of patients (Fig 7). Cutaneous symptoms can be accompanied by fever, lymphadenopathy (Fig 8), arthralgias, poor general condition, and morbilliform exanthema in a nonnegligible percentage of patients (Fig 9). In addition to the genitalia (Figs 10 and 11), the perianal area (Fig 12), the face (Figs 13 to 15), and the oral (Fig 16) and pharyngeal mucosa (Figs 17 and 18) may be affected.3 3 Palmoplantar involvement (Fig 19) ranges from 7% to 20% in most series and a specific presentation known as monkeypox whitlow (Fig 20) has been described in some patients. Atypical manifestations of infection include inguinal patch (Fig 21)4 4 and anetoderma (Fig 22).5 5