Analyzing the unperturbed HIV-1 T cell reservoir

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2023 English Publisher:Elsevier BVJournal:Trends in Immunology, volume 44, pages 147-149 (issn: 1471-4906,

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Authors: Brianna, Lopez; Robert F, Siliciano;

doi: 10.1016/j.it.2023.01.007

pmid: 36739207

Analyzing the unperturbed HIV-1 T cell reservoir

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Abstract

The latent reservoir for HIV-1 prevents cure but is difficult to characterize due to the low frequency of latently infected cells and the absence of unique markers. Sun et al. used single cell analysis of T cell surface phenotypes to provide evidence for immune selection of reservoir cells.

Related Organizations

Johns Hopkins Medicine
United States
Howard Hughes Medical Institute
United States

Keywords

CD4-Positive T-Lymphocytes, HIV-1, Humans, HIV Infections, Virus Replication, Virus Latency

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