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Instructing Memory in CD8+ Thymocytes

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2020 English Publisher:Elsevier BVJournal:Trends in Immunology, volume 41, pages 556-558 (issn: 1471-4906,

Authors: Kristin A. Hogquist; Katherine Maude Ashby;

doi: 10.1016/j.it.2020.05.006

pmid: 32518054

pmc: PMC7558811

Instructing Memory in CD8+ Thymocytes

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Abstract

T cells can sometimes acquire properties of a memory cell without encountering foreign antigen. Miller et al. now show that development of such 'memory phenotype' (MP) CD8+ T cells starts with recognition of self-ligands in the thymus, and finishes in peripheral tissues. These cells respond rapidly during infection, and infiltrate tumors, where they express high amounts of PD-1.

Related Organizations

University of Minnesota Morris
United States

Keywords

Phenotype, Thymocytes, Humans, CD8-Positive T-Lymphocytes, T-Box Domain Proteins

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