NKG2D Signaling: The Immune Subversive Side of HDAC3
Copyright policy )NKG2D Signaling: The Immune Subversive Side of HDAC3
Natural killer (NK) cells are alerted to infected and transformed cells by local upregulation of ligands for the NK-activating receptor NKG2D. In a recent report, Greene et al. unveil a new mechanism that induces the expression of the NKG2D ligand retinoic acid early-inducible (RAE-1) in response to murine cytomegalovirus (MCMV) infection through inhibition of casein kinase 2 (CK2), an activator of the repressor histone deacetylase HDAC3.
Cytotoxicity, Immunologic, Muromegalovirus, Membrane Proteins, Herpesviridae Infections, Histone Deacetylases, Immunity, Innate, Epigenesis, Genetic, Histone Deacetylase 3, Killer Cells, Natural, Mice, HEK293 Cells, Sp3 Transcription Factor, NK Cell Lectin-Like Receptor Subfamily K, Animals, Humans, Casein Kinase II, Signal Transduction
Cytotoxicity, Immunologic, Muromegalovirus, Membrane Proteins, Herpesviridae Infections, Histone Deacetylases, Immunity, Innate, Epigenesis, Genetic, Histone Deacetylase 3, Killer Cells, Natural, Mice, HEK293 Cells, Sp3 Transcription Factor, NK Cell Lectin-Like Receptor Subfamily K, Animals, Humans, Casein Kinase II, Signal Transduction
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