Regulation of the T Cell Response by CD39
Copyright policy )Regulation of the T Cell Response by CD39
The ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1, or CD39) catalyzes the phosphohydrolysis of extracellular ATP (eATP) and ADP (eADP) released under conditions of inflammatory stress and cell injury. CD39 generates AMP, which is in turn used by the ecto-5'-nucleotidase CD73 to synthesize adenosine. These ectonucleotidases have a major impact on the dynamic equilibrium of proinflammatory eATP and ADP nucleotides versus immunosuppressive adenosine nucleosides. Indeed, CD39 plays a dominant role in the purinergic regulation of inflammation and the immune response because its expression is influenced by genetic and environmental factors. We review the specific role of CD39 in the kinetic regulation of cellular immune responses in the evolution of disease. We focus on the effects of CD39 on T cells and explore potential clinical applications in autoimmunity, chronic infections, and cancer.
- Harvard University United States
- Massachusetts Institute of Technology United States
- Beth Israel Deaconess Medical Center United States
- Brigham and Women's Faulkner Hospital United States
Inflammation, Adenosine, T-Lymphocytes, Apyrase, Autoimmunity, Infections, Lymphocyte Activation, Adenosine Monophosphate, Autoimmune Diseases, Antigens, CD, Neoplasms, Immune Tolerance, Animals, Humans, Gene-Environment Interaction, 5'-Nucleotidase
Inflammation, Adenosine, T-Lymphocytes, Apyrase, Autoimmunity, Infections, Lymphocyte Activation, Adenosine Monophosphate, Autoimmune Diseases, Antigens, CD, Neoplasms, Immune Tolerance, Animals, Humans, Gene-Environment Interaction, 5'-Nucleotidase
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