Reprogramming antitumor immunity

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2014 English Publisher:Elsevier BVJournal:Trends in Immunology, volume 35, pages 178-185 (issn: 1471-4906,

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Authors: Joseph G, Crompton; David, Clever; Raul, Vizcardo; Mahendra, Rao; Nicholas P, Restifo;

doi: 10.1016/j.it.2014.02.003

pmid: 24661777

pmc: PMC4373650

Reprogramming antitumor immunity

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Abstract

Regenerative medicine holds great promise in replacing tissues and organs lost to degenerative disease and injury. Application of the principles of cellular reprogramming for the treatment of cancer, however, is not well established. Here, we present an overview of cellular reprogramming techniques used in regenerative medicine, and within this context, envision how the scope of regenerative medicine may be expanded to treat metastatic cancer by revitalizing an exhausted and senescent immune system.

Related Organizations

National Institutes of Health
United States
National Institute of Health
Pakistan
University of California, Los Angeles
United States
Center for Neuroscience and Regenerative Medicine
United States
National Cancer Institute
United States

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Keywords

Neoplasms, Animals, Humans, Immunotherapy, Cellular Reprogramming, Regenerative Medicine

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