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Trends in Immunology
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Trends in Immunology
Article . 2011 . Peer-reviewed
License: Elsevier TDM
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https://pubmed.ncbi.nlm.nih.go...
Article . 2011
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https://dx.doi.org/10.1016/j.i...
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Article . 2022
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Complex regulation and function of activation-induced cytidine deaminase

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2011 United States English Publisher:Elsevier BVJournal:Trends in Immunology, volume 32, pages 194-201 (issn: 1471-4906, Copyright policy )
Authors: Stavnezer, Janet;

doi: 10.1016/j.it.2011.03.003

pmid: 21493144

pmc: PMC3090464

handle: 20.500.14038/36498

Complex regulation and function of activation-induced cytidine deaminase

Abstract

Activation-induced cytidine deaminase (AID) instigates mutations and DNA breaks in Ig genes that undergo somatic hypermutation and class switch recombination during B cell activation in response to immunization and infection. This review discusses how AID expression and activity are regulated, including recent discoveries of AID-interacting proteins that might recruit AID to Ig genes, and allow it to target both DNA strands. Also discussed is the accumulating evidence that AID binds to, mutates, and creates breaks at numerous non-Ig sites in the genome, which initiates cell transformation and malignancies.

Country
United States
Related Organizations
Keywords

Enzymologic, B-Lymphocytes, AICDA (Activation-Induced Cytidine Deaminase), DNA, Superhelical, *Gene Expression Regulation, RNA Stability, Genetics and Genomics, DNA, Somatic Hypermutation, Lymphocyte Activation, Immunoglobulin Class Switching, Gene Expression Regulation, Enzymologic, Mice, Cytidine Deaminase, Immunoglobulin, Animals, Humans, Somatic Hypermutation, Immunoglobulin, Superhelical, Immunology and Infectious Disease

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    selected citations
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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 106
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 1%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
106
Top 10%
Top 10%
Top 1%
bronze
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