CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns
Copyright policy )CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns
It is now well accepted that the innate immune system recognizes both damage (or danger)- and pathogen-associated molecular patterns (DAMP and PAMP, respectively) through pattern recognition receptors, such as Toll-like receptors (TLR) and/or Nod-like receptors (NLR). Less clear are whether and how the response to PAMP and DAMP are regulated differentially. The answers may reveal whether the primary goal of the immune system is to defend against infections or to alert the host of tissue injuries. We demonstrated recently that the host response to DAMP is controlled by a DAMP-CD24-Siglec axis. Here we propose a key role for the CD24-Siglec pathway in discriminating between DAMPs and PAMPs.
- University of Michigan–Flint United States
- University of Michigan–Ann Arbor United States
Sialic Acid Binding Immunoglobulin-like Lectins, Protein Tyrosine Phosphatase, Non-Receptor Type 6, CD24 Antigen, Lymphocyte Activation, Immunity, Innate, Toll-Like Receptor 2, Toll-Like Receptor 4, Mice, Lectins, Nod1 Signaling Adaptor Protein, Receptors, Pattern Recognition, Animals, Humans, Heat-Shock Proteins, Protein Binding
Sialic Acid Binding Immunoglobulin-like Lectins, Protein Tyrosine Phosphatase, Non-Receptor Type 6, CD24 Antigen, Lymphocyte Activation, Immunity, Innate, Toll-Like Receptor 2, Toll-Like Receptor 4, Mice, Lectins, Nod1 Signaling Adaptor Protein, Receptors, Pattern Recognition, Animals, Humans, Heat-Shock Proteins, Protein Binding
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