This paper addresses model-based prognosis to predict Remaining Useful Life (RUL) of a class of dynamical systems. The methodology is based on singular perturbed techniques to take into account the slow behavior of degradations. The full-order system is firstly decoupled into slow and fast subsystems. An interval observer is designed for both subsystems under the assumption that the measurement noise and the disturbances are bounded. Then, the degradation is modeled as a polynomial whose parameters are estimated using ellipsoid algorithms. Finally, the RUL is predicted based on an interval evaluation of the degradation model over a time horizon. A numerical example illustrates the proposed technique.