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Immunity
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Immunity
Article . 2020 . Peer-reviewed
License: Elsevier Non-Commercial
Data sources: Crossref
https://pubmed.ncbi.nlm.nih.go...
Article . 2021
Data sources: Europe PubMed Central
https://dx.doi.org/10.1016/j.i...
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Snapshot of a Deadly Embrace: The Caspase-1-GSDMD Interface

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2020 English Publisher:Elsevier BVJournal:Immunity, volume 53, pages 6-8 (issn: 1074-7613, Copyright policy )
Authors: Lieselotte, Vande Walle; Mohamed, Lamkanfi;

doi: 10.1016/j.immuni.2020.06.019

pmid: 32668229

Snapshot of a Deadly Embrace: The Caspase-1-GSDMD Interface

Abstract

Proteolytic maturation of the pore-forming protein gasdermin D (GSDMD) by inflammasome-activated caspase-1 is crucial for initiating pyroptosis, a lytic form of cell death. In this issue of Immunity, Lui et al. report the X-ray structure of the caspase-1-GSDMD complex, mapping the interaction interfaces that determine recognition and cleavage of GSDMD by inflammatory caspases.

Related Organizations
Keywords

Inflammasomes, Caspases, Caspase 1, Intracellular Signaling Peptides and Proteins, Pyroptosis, Phosphate-Binding Proteins, Neoplasm Proteins

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 19
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
19
Top 10%
Average
Top 10%
hybrid