The Yolk Sac Feeds Pancreatic Tumors

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2017 United Kingdom English Publisher:Elsevier BVJournal:Immunity, volume 47, pages 217-218 (issn: 1074-7613,

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Authors: Pollard, Jeffrey;

doi: 10.1016/j.immuni.2017.07.021

pmid: 28813653

handle: 20.500.11820/f1eb0cdf-86e6-405c-9c88-d1c207d33bff

The Yolk Sac Feeds Pancreatic Tumors

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Abstract

In this issue of Immunity, Zhu et al. (2017) report that tumor-associated macrophages in a mouse model of pancreatic ductal adenocarcinoma (PDAC) originate from both the yolk sac (YS) and bone marrow. Differential ablation of these populations indicates that only the YS-derived macrophages promote PDAC progression and growth.

Country

United Kingdom

Related Organizations

Yeshiva University
United States
Albert Einstein College of Medicine
United States
The Queen's Medical Research Institute
United Kingdom
University of Edinburgh
United Kingdom

Keywords

Bone Marrow, Macrophages, Animals, Pancreas, Carcinoma, Pancreatic Ductal, Yolk Sac

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