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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Immunology Lettersarrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
Immunology Letters
Article . 2025 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
https://pubmed.ncbi.nlm.nih.go...
Article
Data sources: Europe PubMed Central
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Soluble CTLA-4 – A confounding factor in CTLA-4 based checkpoint immunotherapy in cancer

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2025 English Publisher:Elsevier BVJournal:Immunology Letters, volume 272, page 106,965 (issn: 0165-2478, Copyright policy )
Authors: Parviz Azimnasab-sorkhabi; Maryam Soltani-asl; Musab Bouhajra; Ephraim A. Ansa-Addo; Jose Roberto Kfoury Junior;

doi: 10.1016/j.imlet.2024.106965

pmid: 39667581

Soluble CTLA-4 – A confounding factor in CTLA-4 based checkpoint immunotherapy in cancer

Abstract

Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is a receptor that inhibits the activity of T cells. The CTLA-4 gene consists of four different exons that enable four different isoforms of CTLA-4 to be generated through alternative splicing. Although sCTLA-4 might impede the therapeutic effect of anti-CTLA-4 treatments, the role of sCTLA-4 in the tumor microenvironment (TME) is not well understood. Here, we provide novel perspectives on the inhibitory characteristics of sCTLA-4 in TME.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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