Tregs and Th17 lymphocytes in human DYRK1A haploinsufficiency
Copyright policy )Tregs and Th17 lymphocytes in human DYRK1A haploinsufficiency
The DYRK1A gene encodes for a dual-specific tyrosine phosphorylation-regulated kinase 1A involved in different cellular processes such as cell differentiation, proliferation and survival. This tyrosine kinase plays a key role in brain growth and function. Indeed, haploinsufficiency of DYRK1A results in defective kinase activity and is responsible for mental retardation autosomal dominant 7 (MRD7).
- University of Trieste Italy
- University of Turin Italy
- University of Brescia Italy
- University of Padua Italy
- University of Pavia Italy
Male, Protein Serine-Threonine Kinase, Child, Preschool; Genetic Diseases, Inborn; Haploinsufficiency; Humans; Intellectual Disability; Male; Middle Aged; Protein-Serine-Threonine Kinases; Protein-Tyrosine Kinases; T-Lymphocytes, Regulatory; Th17 Cells, T-Lymphocytes, Haploinsufficiency, DYRK1A; Tregs; MRD7, DYRK1A, Middle Aged, Regulatory, Treg, Inborn, Genetic Diseases, Intellectual Disability, Protein-Tyrosine Kinase, MRD7, Th17 Cells, Child, Preschool, Human
Male, Protein Serine-Threonine Kinase, Child, Preschool; Genetic Diseases, Inborn; Haploinsufficiency; Humans; Intellectual Disability; Male; Middle Aged; Protein-Serine-Threonine Kinases; Protein-Tyrosine Kinases; T-Lymphocytes, Regulatory; Th17 Cells, T-Lymphocytes, Haploinsufficiency, DYRK1A; Tregs; MRD7, DYRK1A, Middle Aged, Regulatory, Treg, Inborn, Genetic Diseases, Intellectual Disability, Protein-Tyrosine Kinase, MRD7, Th17 Cells, Child, Preschool, Human
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