Chimeric antigen receptors (CARs) from bench-to-bedside

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2013 English Publisher:Elsevier BVJournal:Immunology Letters, volume 155, pages 40-42 (issn: 0165-2478,

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Authors: Barbara, Savoldo; Gianpietro, Dotti;

doi: 10.1016/j.imlet.2013.09.014 , 10.17615/kkbc-nb60

pmid: 24080488

pmc: PMC3926092

Chimeric antigen receptors (CARs) from bench-to-bedside

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Abstract

Chimeric antigen receptors (CARs) combine the antigen specificity of an antibody with the biologic properties of T lymphocytes. While the concept has been developed more than 20 years ago, only in recent years the clinical application of this approach has produced remarkable objective clinical responses. In this brief review, we outline some specific aspects that have led to antitumor responses in cancer patients.

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Keywords

Recombinant Fusion Proteins, T-Lymphocytes, Genetic Therapy, Cancer Vaccines, Immunotherapy, Adoptive, Antibodies, Receptors, Antigen, Neoplasms, Animals, Humans

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