Abstract Lubrication oil used in refrigerant compressors forms oil mist in the compressor shell. Some of the oil mist is discharged into a refrigeration cycle with refrigerant and causes degradation of heat transfer in heat exchangers. Since the generation of the oil mist is related to the Weber number, it is necessary to measure the surface tension of the oil/refrigerant mixture before discussing the oil mist generation in the compressor. In this study, the maximum bubble pressure method was adapted to measure the surface tension of PAG (polyalkylene glycol) oil/CO2 mixture. The density of the mixture needed for the measurement was also carried out. It was found that the surface tension of PAG/CO2 mixture sharply decreases with an increase in the concentration of the refrigerant in the mixture. The surface tension of the mixture under 10 MPa and 100 °C is estimated to be 14.6 mN m−1 by an extrapolation.