Postmenopausal gestational trophoblastic neoplasia (GTN) is extremely rare and its pathogenesis unknown. As GTN is not considered in the differential diagnosis of postmenopausal uterine malignancies its preoperative diagnosis is challenging. To the authors knowledge only 1 case of postmenopausal invasive mole diagnosed postmortem has so far been reported in the English-language literature [1]. A 53-year-old multipara presented with abdominal pain which she had been experiencing for 1 week. Her last delivery at term had occurred 15 years previously and her last pregnancy had been terminated in its eighth week by dilation and curettage 8 years previously. The patient had been in natural menopause for 2 years with no history of GTN during her reproductive years postmenopausal bleeding or hormone therapy. She was sexually active. (excerpt)