Abstract Basic biomedical sciences form foundation for enlightened rational clinical practice and provide substance for innovation and advance. Tooth eruption is highly complex yet finely regulated process of developmental biology. Integration of local, regional and systemic mechanisms is uniquely displayed in eruption physiology. Serial and reciprocal gene expressions in the process enable parallel progress of opposite biologic process in close proximity. Rational clinical address to eruption disorders can only be based on sound understanding of basic physiologic process. Scope for developing enhanced therapeutic capabilities and pharmaceuticals must emerge through understanding and investigation on the perspectives. This review attempts to briefly present simplified view of physiology of tooth eruption drawn on the current understanding.