Abstract In this paper, we analyze the effect of the internal structure of a parent body on its fragment properties following its disruption in different impact energy regimes. To simulate an asteroid breakup, we use the same numerical procedure as in our previous studies, i.e., a 3D SPH hydrocode to compute the fragmentation phase and the parallel N-body code pkdgrav to compute the subsequent gravitational re-accumulation phase. To explore the importance of the internal structure in determining the collisional outcome, we consider two different parent body models: (1) a purely monolithic one and (2) a pre-shattered one which consists of several fragments separated by damaged zones and small voids. We present here simulations spanning two different impact energy regimes—barely disruptive and highly catastrophic—corresponding to the formation of the Eunomia and Koronis families, respectively. As we already found for the intermediate energy regime represented by the Karin family, pre-shattered parent bodies always lead to outcome properties in better agreement with those of real families. In particular, the fragment size distribution obtained by disrupting a monolithic body always contains a large gap between the largest fragment and the next largest ones, whereas it is much more continuous in the case of a pre-shattered parent body. In the latter case, the ejection speeds of large fragments are also higher and a smaller impact energy is generally required to achieve a similar degree of disruption. Hence, unless the internal structure of bodies involved in a collision is known, predicting accurately the outcome is impossible. Interestingly, disrupting a pre-shattered parent body to reproduce the Koronis family yields a fragment size distribution characterized by four almost identical largest objects, as observed in the real family. This peculiar outcome has been found before in laboratory experiments but is obtained for the first time following gravitational re-accumulation. Finally, we show that material belonging to the largest fragments of a family originates from well-defined regions inside the parent body (the extent and location of which are dependent upon internal structure), despite the many gravitational interactions that occur during the re-accumulation process. Hence fragment formation does not proceed stochastically but results directly from the velocity field imparted during the impact.