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A History of Bone Marrow Transplantation

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2010 English Publisher:Elsevier BVJournal:Immunology and Allergy Clinics of North America, volume 30, pages 1-15 (issn: 0889-8561,

Authors: Richard A. Gatti; M. Teresa de la Morena;

doi: 10.1016/j.iac.2009.11.005 , 10.1016/j.hoc.2010.11.001

pmid: 21236386 , 20113883

A History of Bone Marrow Transplantation

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Abstract

The last 40 years has seen the emergence of hematopoietic stem cell transplantation as a therapeutic modality for fatal diseases and as a curative option for individuals born with inherited disorders that carry limited life expectancy and poor quality of life. Despite the rarity of many primary immunodeficiency diseases, these disorders have led the way toward innovative therapies and further provide insights into mechanisms of immunologic reconstitution applicable to all hematopoietic stem cell transplants. This article represents a historical perspective of the early investigators and their contributions. It also reviews the parallel work that oncologists and immunologists have undertaken to treat both primary immunodeficiencies and hematologic malignancies.

Related Organizations

University of California, Los Angeles
United States
The University of Texas Southwestern Medical Center
United States
University of Chicago
United States

Keywords

Allergy and Immunology, Hematologic Neoplasms, Hematopoietic Stem Cell Transplantation, Immunologic Deficiency Syndromes, Humans, Bone Marrow Cells, Hematopoietic Stem Cells, Medical Oncology, Bone Marrow Transplantation

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	74
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%