Fluoroquinolones are commonly prescribed antibiotics used to treat a variety of infections including respiratory infections, sexually transmitted diseases, urinary tract infections, and skin and soft tissue infections. A wide range of fluoroquinolone-induced CNS side-effects are reported in the literature [1,2]. In comparison with other systemic antibiotics, adverse CNS events were significantly higher with fluroquinolone use [2]. Studies of fluoroquinolones have noted CNS toxicity occur in approximately 1.0–4.4% of patients [3], but with serious side-effects occurring in b0.5% of patients [3–5]. Common side-effects are noted to be headache, dizziness and insomnia. Rare but more serious side-effects reported in the product literature include tremors, restlessness, anxiety, lightheadedness, confusion, hallucinations, paranoia, depression, nightmares, insomnia and suicidal thoughts or acts [6]. Case reports have documented fluoroquinoloneinduced psychosis [7–10], catatonia [11], seizures [12] and delirium [13]. Some differences have been noted within the safety profiles of individual fluoroquinolones, with rufloxacin and ofloxacin being more frequently associated with psychiatric symptoms [2,14]. Among the fluoroquinolones, levofloxacin has been considered to be a safe medication, with the overall incidence of drug-related CNS side-effects found in clinical trials to be b1% [15], and no reports in the literature of suicidal ideation. We present a case of a man with no past psychiatric history who presented with severe depression and suicidal ideation after taking levofloxacin, which then quickly remitted after discontinuing the medication.