Regulation of the PTEN phosphatase
Copyright policy )Regulation of the PTEN phosphatase
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a phosphatidylinositol phosphate phosphatase and is frequently inactivated in human cancers. The balance between phosphoinositide 3-kinase (PI3K) and PTEN determines PI(3,4,5)P3 levels. PI3K is regulated by a variety of intracellular and extracellular signals, but little is known about the regulation of PTEN. In this article, we review control of PTEN function by phosphorylation as well as by binding of lipid and protein partners.
- University System of Ohio United States
- Kent State University United States
- University of Massachusetts Medical School United States
Tumor Suppressor Proteins, PTEN Phosphohydrolase, Lipid Metabolism, Phosphoric Monoester Hydrolases, Protein Structure, Tertiary, Phosphatidylinositol Phosphates, Animals, Humans, Phosphorylation, Protein Binding
Tumor Suppressor Proteins, PTEN Phosphohydrolase, Lipid Metabolism, Phosphoric Monoester Hydrolases, Protein Structure, Tertiary, Phosphatidylinositol Phosphates, Animals, Humans, Phosphorylation, Protein Binding
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