Lipid peroxidation in the pathogenesis of neuroborreliosis
Copyright policy )Lipid peroxidation in the pathogenesis of neuroborreliosis
This study analyzed the onset of lipid peroxidation (LPO) in neuroborreliosis and the effects of ceftriaxone therapy on LPO. Twenty-two patients with early neuroborreliosis and 22 healthy subjects were studied. LPO in the cerebrospinal fluid (CSF), as well as the plasma and urine was estimated by the levels of reactive aldehydes: 4-hydroxynonenal (4-HNE), 4-hydroxyhexenal, malondialdehyde, and 4-oxononenal, F2-isoprostanes and A4/J4-neuroprostanes (NPs). The plasma level of 4-HNE-protein adducts arachidonic acid (AA), docosahexaenoic acid (DHA) and vitamin E was determined. Additionally, enzymatic activities of phospholipase A2 (PLA2), platelet-activating factor acetylhydrolase (PAF-AH) and glutathione peroxidase (GSH-Px) were determined. A decrease of AA, DHA levels and GSH-Px activity in plasma was associated with a significant increase of aldehydes in the CSF, plasma and urine. Similarly, the increase of F2-isoprostanes and NPs in the CSF and plasma was associated with the decreased activity of PLA2 and PAF-AH. Ceftriaxone therapy cured patients and reduced the levels of F2-isoprostanes, NPs and reactive aldehydes. However, the activities of PLA2 and PAF-AH increased. Pathophysiological association of neuroborreliosis with systemic LPO was revealed. Effective antibiotic therapy attenuated LPO. Biomarkers of LPO could be useful to monitor the onset of neuroborreliosis and show the effectiveness of pharmacotherapy.
- Wrocław Medical University Poland
- Medical University of Białystok Poland
- Ruđer Bošković Institute Croatia
Male, Neuroborelioza z Lyme - krew, F2 - izoprostany - mocz, Oxidative stress - genetics, Urine, Kwasy dokozaheksanowe - metabolizm, F 2-isoprostanes - blood, Plasma, Neuroborelioza z Lyme - płyn mózgowo-rdzeniowy, F 2-isoprostanes - urine, Stres oksydacyjny - genetyka, Malondialdehyde, 80 and over, Borrelia burgdorferi - metabolizm, Lyme neuroborreliosis - drug therapy, Aged, 80 and over, F2-Isoprostanes, Borrelia burgdorferi - metabolism, Malondialdehyde - blood, Neuroborreliosis, Ceftriaxone, Middle Aged, Aldehydes - blood, F(2)-isoprostaneas, Phospholipases, F 2-isoprostanes - cerebrospinal fluid, Borrelia burgdorferi - chorobotwórczość, Osoby w wieku podeszłym, Female, Aldehydy - płyn mózgowo-rdzeniowy, Dialdehyd malonowy - krew, Lyme neuroborreliosis - blood, Aldehydy - mocz, Neuroborelioza z Lyme - farmakoterapia, Osoby w wieku ponad 80 lat, Reactive aldehydes, Adult, Docosahexaenoic Acids, F2 - izoprostany - krew, Stres oksydacyjny - wpływ środków chemicznych, Neuroborelioza z Lyme - mocz, Docosahexaenoic acids - metabolism, Lipid peroxidation, CSF, Malondialdehyde - urine, Peroksydaza glutationowa - genetyka, Fosfolipazy A2 - krew, Lyme neuroborreliosis - cerebrospinal fluid, Aldehydes - cerebrospinal fluid, Aldehydes - urine, 4-Hydroxy-2-nonenal ; CSF ; F(2)-isoprostaneas ; Fatty acids ; Lipid peroxidation ; Neuroborreliosis ; Neuroprostanes ; Phospholipases ; Plasma ; Reactive aldehydes ; Urine, Phospholipases A 2 - blood, Borrelia burgdorferi - pathogenicity, Peroksydacja lipidów - wpływ środków chemicznych, Neuroprostanes, Humans, Lyme Neuroborreliosis, Fatty acids, Malondialdehyde - cerebrospinal fluid, Aged, Lipid peroxidation - drug effects, Lyme neuroborreliosis - urine, Aldehydes, Glutathione Peroxidase, Oxidative stress - drug effects, Oxidative Stress, Phospholipases A2, Glutathione peroxidase - genetics, F2 - izoprostany - płyn mózgowo-rdzeniowy, Borrelia burgdorferi, Dialdehyd malonowy - płyn mózgowo-rdzeniowy, 4-Hydroxy-2-nonenal, Aldehydy - krew, Lipid Peroxidation, Dialdehyd malonowy - mocz
Male, Neuroborelioza z Lyme - krew, F2 - izoprostany - mocz, Oxidative stress - genetics, Urine, Kwasy dokozaheksanowe - metabolizm, F 2-isoprostanes - blood, Plasma, Neuroborelioza z Lyme - płyn mózgowo-rdzeniowy, F 2-isoprostanes - urine, Stres oksydacyjny - genetyka, Malondialdehyde, 80 and over, Borrelia burgdorferi - metabolizm, Lyme neuroborreliosis - drug therapy, Aged, 80 and over, F2-Isoprostanes, Borrelia burgdorferi - metabolism, Malondialdehyde - blood, Neuroborreliosis, Ceftriaxone, Middle Aged, Aldehydes - blood, F(2)-isoprostaneas, Phospholipases, F 2-isoprostanes - cerebrospinal fluid, Borrelia burgdorferi - chorobotwórczość, Osoby w wieku podeszłym, Female, Aldehydy - płyn mózgowo-rdzeniowy, Dialdehyd malonowy - krew, Lyme neuroborreliosis - blood, Aldehydy - mocz, Neuroborelioza z Lyme - farmakoterapia, Osoby w wieku ponad 80 lat, Reactive aldehydes, Adult, Docosahexaenoic Acids, F2 - izoprostany - krew, Stres oksydacyjny - wpływ środków chemicznych, Neuroborelioza z Lyme - mocz, Docosahexaenoic acids - metabolism, Lipid peroxidation, CSF, Malondialdehyde - urine, Peroksydaza glutationowa - genetyka, Fosfolipazy A2 - krew, Lyme neuroborreliosis - cerebrospinal fluid, Aldehydes - cerebrospinal fluid, Aldehydes - urine, 4-Hydroxy-2-nonenal ; CSF ; F(2)-isoprostaneas ; Fatty acids ; Lipid peroxidation ; Neuroborreliosis ; Neuroprostanes ; Phospholipases ; Plasma ; Reactive aldehydes ; Urine, Phospholipases A 2 - blood, Borrelia burgdorferi - pathogenicity, Peroksydacja lipidów - wpływ środków chemicznych, Neuroprostanes, Humans, Lyme Neuroborreliosis, Fatty acids, Malondialdehyde - cerebrospinal fluid, Aged, Lipid peroxidation - drug effects, Lyme neuroborreliosis - urine, Aldehydes, Glutathione Peroxidase, Oxidative stress - drug effects, Oxidative Stress, Phospholipases A2, Glutathione peroxidase - genetics, F2 - izoprostany - płyn mózgowo-rdzeniowy, Borrelia burgdorferi, Dialdehyd malonowy - płyn mózgowo-rdzeniowy, 4-Hydroxy-2-nonenal, Aldehydy - krew, Lipid Peroxidation, Dialdehyd malonowy - mocz
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