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Sequencing methods and functional decoding of mRNA modifications

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Sep 2023Publisher:Elsevier BVJournal:Fundamental Research, volume 3, pages 738-748 (issn: 2667-3258,

Authors: Kai Li; Jinying Peng; Chengqi Yi;

doi: 10.1016/j.fmre.2023.05.010

pmid: 38933299

pmc: PMC11197720

Sequencing methods and functional decoding of mRNA modifications

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Abstract

More than 160 types of post-transcriptional RNA modifications have been reported; there is substantial variation in modification type, abundance, site, and function across species, tissues, and RNA type. The recent development of high-throughput detection technology has enabled identification of diverse dynamic and reversible RNA modifications, including N6,2'-O-dimethyladenosine (m6Am), N1-methyladenosine (m1A), 5-methylcytosine (m5C), N6-methyladenosine (m6A), pseudouridine (Ψ), and inosine (I). In this review, we focus on eukaryotic mRNA modifications. We summarize their biogenesis, regulatory mechanisms, and biological functions, as well as high-throughput methods for detection of mRNA modifications. We also discuss challenges that must be addressed in mRNA modification research.

Related Organizations

Center for Life Sciences
China (People's Republic of)
State Key Laboratory of Protein and Plant Gene Research
China (People's Republic of)
Peking University
China (People's Republic of)

Keywords

N6,2′-O-dimethyladenosine (m6Am), Q1-390, Science (General), N1-methyladenosine (m1A), 5-Methylcytosine (m5C), N6-methyladenosine (m6A), Pseudouridine (Ψ), Review, RNA modification

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