IVF and retinoblastoma revisited
Copyright policy )IVF and retinoblastoma revisited
To evaluate the suggested association between IVF, retinoblastoma, and tumor methylation characteristics.Laboratory analysis.National Retinoblastoma Center in the Netherlands.Retinoblastoma tumors from seven children conceived by IVF or intracytoplasmic sperm injection (ICSI).DNA from frozen retinoblastoma tumors was tested for mutations in the RB1 gene and for methylation status of the RB1 promoter.For all tumors two causative RB1 mutations were found. None of the tumors showed hypermethylation of the RB1 promoter.Examination of retinoblastoma tumors of seven children conceived by IVF or ICSI did not show hypermethylation of the RB1 promoter. This demonstrates that an association between IVF or ICSI and retinoblastoma through this epigenetic mechanism is unlikely.
- Amsterdam UMC Netherlands
- Amsterdam UMC, location VUmc Netherlands
- University Medical Center Groningen Netherlands
- University Medical Center United States
- University of Groningen Netherlands
EXPRESSION, Male, NCEBP 1: Molecular epidemiology ONCOL 5: Aetiology, screening and detection, Retinal Neoplasms, Fertilization in Vitro, SPORADIC RETINOBLASTOMA, Retinoblastoma Protein, Epigenesis, Genetic, Cohort Studies, Humans, Sperm Injections, Intracytoplasmic, Promoter Regions, Genetic, Netherlands, RB1 gene, DNA methylation, MUTATIONS, Retinoblastoma, MOUSE EMBRYO, Infant, ASSOCIATION, BECKWITH-WIEDEMANN-SYNDROME, INTRACYTOPLASMIC SPERM INJECTION, DNA Methylation, GENE, Child, Preschool, TECHNOLOGIES, Female, IN-VITRO FERTILIZATION, in vitro fertilization
EXPRESSION, Male, NCEBP 1: Molecular epidemiology ONCOL 5: Aetiology, screening and detection, Retinal Neoplasms, Fertilization in Vitro, SPORADIC RETINOBLASTOMA, Retinoblastoma Protein, Epigenesis, Genetic, Cohort Studies, Humans, Sperm Injections, Intracytoplasmic, Promoter Regions, Genetic, Netherlands, RB1 gene, DNA methylation, MUTATIONS, Retinoblastoma, MOUSE EMBRYO, Infant, ASSOCIATION, BECKWITH-WIEDEMANN-SYNDROME, INTRACYTOPLASMIC SPERM INJECTION, DNA Methylation, GENE, Child, Preschool, TECHNOLOGIES, Female, IN-VITRO FERTILIZATION, in vitro fertilization
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