Role of anti-β-glucan antibody in host defense against fungi
Copyright policy )Role of anti-β-glucan antibody in host defense against fungi
We have recently detected an anti-beta-glucan antibody in normal human and normal mouse sera. The anti-beta-glucan antibody showed reactivity to pathogenic fungal Aspergillus and Candida cell wall glucan. Anti-beta-glucan antibody could bind whole Candida cells. It also enhanced the candidacidal activity of macrophages in vitro. The anti-beta-glucan antibody titer of DBA/2 mice intravenously administered either Candida or Aspergillus solubilized cell wall beta-glucan decreased remarkably dependent on dose. Moreover, in deep mycosis patients, the anti-beta-glucan antibody titer decreased, and this change correlated with clinical symptoms and other parameters such as C-reactive protein. It was suggested that the anti-beta-glucan antibody formed an antigen-antibody complex and participated in the immune response as a molecule recognizing pathogenic fungi.
Male, Antigens, Fungal, beta-Glucans, Candidiasis, Antigen-Antibody Complex, In Vitro Techniques, Immunity, Innate, Mice, Aspergillus, Antibody Specificity, Cell Wall, Mice, Inbred DBA, Animals, Aspergillosis, Humans, Female, Antibodies, Fungal, Candida
Male, Antigens, Fungal, beta-Glucans, Candidiasis, Antigen-Antibody Complex, In Vitro Techniques, Immunity, Innate, Mice, Aspergillus, Antibody Specificity, Cell Wall, Mice, Inbred DBA, Animals, Aspergillosis, Humans, Female, Antibodies, Fungal, Candida
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