Diacylglycerol kinase η1 is a high affinity isozyme for diacylglycerol
Copyright policy )Diacylglycerol kinase η1 is a high affinity isozyme for diacylglycerol
Diacylglycerol kinase (DGK) η plays important roles in various patho‐physiological events such as oncogenesis. In this study, we performed an enzymological characterization of DGKη splice variant 1 (DGKη1). The K m value for diacylglycerol was 0.14 mol%. Intriguingly, the K m value of DGKη1 for diacylglycerol was at least 9‐fold lower than those of other DGK isozymes including DGKα, indicating that DGKη1 is a high affinity isozyme for diacylglycerol. Therefore, DGKη1 is a unique DGK isozyme, which may function at particular membrane sites where only low concentrations of diacylglycerol are supplied.
- Chiba University Japan
Diacylglycerol Kinase, Swine, Diacylglycerol kinase, High affinity, ATP, Diglycerides, Isoenzymes, Isozyme, Animals, Humans, Diacylglycerol
Diacylglycerol Kinase, Swine, Diacylglycerol kinase, High affinity, ATP, Diglycerides, Isoenzymes, Isozyme, Animals, Humans, Diacylglycerol
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