Lumican: A new inhibitor of matrix metalloproteinase‐14 activity
Copyright policy )Lumican: A new inhibitor of matrix metalloproteinase‐14 activity
We previously showed that lumican regulates MMP‐14 expression. The aim of this study was to compare the effect of lumican and decorin on MMP‐14 activity. In contrast to decorin, the glycosylated form of lumican was able to significantly decrease MMP‐14 activity in B16F1 melanoma cells. Our results suggest that a direct interaction occurs between lumican and MMP‐14. Lumican behaves as a competitive inhibitor which leads to a complete blocking of the activity of MMP‐14. It binds to the catalytic domain of MMP‐14 with moderate affinity (KD∼ 275 nM). Lumican may protect collagen against MMP‐14 proteolysis, thus influencing cell–matrix interaction in tumor progression.
Lumican, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Matrix Metalloproteinase Inhibitors, Binding, Competitive, Small leucine-rich proteoglycan, Mice, Chondroitin Sulfate Proteoglycans, Keratan Sulfate, Cell Line, Tumor, Proteolysis, MMP-14, Matrix Metalloproteinase 14, Animals, Humans, Collagen, Decorin, Molecular Biology
Lumican, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Matrix Metalloproteinase Inhibitors, Binding, Competitive, Small leucine-rich proteoglycan, Mice, Chondroitin Sulfate Proteoglycans, Keratan Sulfate, Cell Line, Tumor, Proteolysis, MMP-14, Matrix Metalloproteinase 14, Animals, Humans, Collagen, Decorin, Molecular Biology
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