RBM10 regulates alternative splicing
Copyright policy )RBM10 regulates alternative splicing
RBM10, originally called S1‐1, is a nuclear RNA‐binding protein with domains characteristic of RNA processing proteins. It has been reported that RBM10 constitutes spliceosome complexes and that RBM5, a close homologue of RBM10, regulates alternative splicing of apoptosis‐related genes, Fas and cFLIP. In this study, we examined whether RBM10 has a regulatory function in splicing similar to RBM5, and determined that it indeed regulates alternative splicing of Fas and Bcl‐x genes. RBM10 promotes exon skipping of Fas pre‐mRNA as well as selection of an internal 5′‐splice site in Bcl‐x pre‐mRNA. We propose a consensus RBM10‐binding sequence at 5′‐splice sites of target exons and a mechanistic model of RBM10 action in the alternative splicing.
- Institute of Science Tokyo Japan
- Osaka Metropolitan University Japan
- Nagoya University Japan
Binding Sites, RBM10, Base Sequence, Tumor Suppressor Proteins, RNA-Binding Proteins, Cell Cycle Proteins, Fas, DNA-Binding Proteins, Isoenzymes, Alternative Splicing, S1-1, Caspases, Consensus Sequence, Humans, RBM5, RNA Splice Sites, RNA, Messenger, fas Receptor, Apoptosis Regulatory Proteins, Alternative splicing, HeLa Cells
Binding Sites, RBM10, Base Sequence, Tumor Suppressor Proteins, RNA-Binding Proteins, Cell Cycle Proteins, Fas, DNA-Binding Proteins, Isoenzymes, Alternative Splicing, S1-1, Caspases, Consensus Sequence, Humans, RBM5, RNA Splice Sites, RNA, Messenger, fas Receptor, Apoptosis Regulatory Proteins, Alternative splicing, HeLa Cells
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