miR‐615‐5p is restrictedly expressed in cirrhotic and cancerous liver tissues and its overexpression alleviates the tumorigenic effects in hepatocellular carcinoma
Copyright policy )miR‐615‐5p is restrictedly expressed in cirrhotic and cancerous liver tissues and its overexpression alleviates the tumorigenic effects in hepatocellular carcinoma
microRNAs aberrant behavior in heptocellular carcinoma (HCC) plays a major role in HCC pathogenesis. miR‐615‐5p expression has never been evaluated in HCC. We showed that miR‐615‐5p was preferentially expressed in HCC, cirrhotic liver tissues and HCC cell lines, but undetected in normal livers. Forced miR‐615‐5p expression in HCC cell lines led to significant decrease in cell growth and migration. In‐silico predication revealed insulin‐like growth factor‐II (IGF‐II) as a potential downstream target for miR‐615‐5p. Forcing the expression of miR‐615‐5p showed downregulation of IGF‐II mRNA, as well as inhibition of the luciferase activity in a luciferase reporter vector harboring the IGF‐II‐3′UTR target sequence. miR‐615‐5p acts as tumor‐suppressor in HCC through targeting IGF‐II.
- University Hospital Heidelberg Germany
- University Hospital Heidelberg Germany
- GERMAN UNIVERSITY IN CAIRO Egypt
- Pathologisches Institut Germany
- German University in Cairo Egypt
Liver Cirrhosis, Carcinoma, Hepatocellular, Proliferation, Down-Regulation, Gene Expression, Cell Movement, Genes, Reporter, Insulin-Like Growth Factor II, Cell Line, Tumor, Humans, Genes, Tumor Suppressor, RNA, Messenger, RNA, Neoplasm, Luciferases, 3' Untranslated Regions, Migration, Cell Proliferation, Base Sequence, Liver Neoplasms, Heptocellular carcinoma, Hep G2 Cells, microRNA-615-5p, MicroRNAs
Liver Cirrhosis, Carcinoma, Hepatocellular, Proliferation, Down-Regulation, Gene Expression, Cell Movement, Genes, Reporter, Insulin-Like Growth Factor II, Cell Line, Tumor, Humans, Genes, Tumor Suppressor, RNA, Messenger, RNA, Neoplasm, Luciferases, 3' Untranslated Regions, Migration, Cell Proliferation, Base Sequence, Liver Neoplasms, Heptocellular carcinoma, Hep G2 Cells, microRNA-615-5p, MicroRNAs
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).52 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!