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Preferential base pairing modes of T·T mismatches

descriptionPublicationkeyboard_double_arrow_right Article 15 Nov 2011 English Publisher:WileyJournal:FEBS Letters, volume 585, pages 3,953-3,958 (issn: 0014-5793, Copyright policy )
Authors: He, Guoyun; Kwok, Chun Kit; Lam, Sik Lok;

doi: 10.1016/j.febslet.2011.10.044

pmid: 22101148

Preferential base pairing modes of T·T mismatches

Abstract

It has long been recognized that T·T mismatches can adopt two different modes of exchangeable wobble base pairs in which no preferential pairing mode has been observed. In this study, we have performed a systematic nuclear magnetic resonance (NMR) investigation to study the sequence context effect on the pairing modes of T·T mismatches. Our results reveal for the first time that preferential pairing mode does exist in T·T mismatches with specific type of flanking base pairs.

Related Organizations
Keywords

Magnetic Resonance Spectroscopy, Base Sequence, Base Pair Mismatch, DNA, Base pairing mode, Base Pairing, NMR, Thymine, T·T mismatch

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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    popularity
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    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
22
Top 10%
Top 10%
Top 10%
bronze