Sobemovirus RNA linked to VPg over a threonine residue
Copyright policy )Sobemovirus RNA linked to VPg over a threonine residue
Positive sense ssRNA virus genomes from several genera have a viral protein genome-linked (VPg) attached over a phosphodiester bond to the 5' end of the genome. The VPgs of Southern bean mosaic virus (SBMV) and Ryegrass mottle virus (RGMoV) were purified from virions and analyzed by mass spectrometry. SBMV VPg was determined to be linked to RNA through a threonine residue at position one, whereas RGMoV VPg was linked to RNA through a serine also at the first position. In addition, we identified the termini of the corresponding VPgs and discovered three and seven phosphorylation sites in SBMV and RGMoV VPgs, respectively. This is the first report on the use of threonine for linking RNA to VPg.
- Tallinn University of Technology Estonia
- Wellcome Centre for Cell Biology United Kingdom
- University of Edinburgh United Kingdom
- University of Tartu Estonia
- Estonian Biocentre Estonia
Threonine, Southern bean mosaic virus, Mass spectrometry, Viral protein genome linked, Molecular Sequence Data, RNA linkage, Genome, Viral, Mass Spectrometry, Viral Proteins, Mosaic Viruses, Ryegrass mottle virus, RNA, Viral, Amino Acid Sequence, Phosphorylation, Protein Processing, Post-Translational, Protein RNA covalent bond
Threonine, Southern bean mosaic virus, Mass spectrometry, Viral protein genome linked, Molecular Sequence Data, RNA linkage, Genome, Viral, Mass Spectrometry, Viral Proteins, Mosaic Viruses, Ryegrass mottle virus, RNA, Viral, Amino Acid Sequence, Phosphorylation, Protein Processing, Post-Translational, Protein RNA covalent bond
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