SUMOylation and de‐SUMOylation in response to DNA damage
Copyright policy )SUMOylation and de‐SUMOylation in response to DNA damage
To maintain genomic integrity, a cell must utilize multiple mechanisms to protect its DNA from the damage generated by environmental agents or DNA metabolism. SUMO (small ubiquitin‐like modifier) can regulate protein stability, protein cellular location, and protein–protein interactions. In this review, we summarize the current understanding of the roles of SUMOylation and de‐SUMOylation in DNA damage response (DDR) and DNA repair with a specific focus on the role of RPA SUMOylation in homologous recombination (HR).
- The University of Texas MD Anderson Cancer Center United States
- St. Luke's Episcopal Hospital United States
- The Texas Heart Institute United States
Recombination, Genetic, DNA Repair, Models, Genetic, SENP, Replication, Sumoylation, DNA, SUMO, Replication Protein A, Animals, Humans, Rad51 Recombinase, RPA, Repair, DNA Damage
Recombination, Genetic, DNA Repair, Models, Genetic, SENP, Replication, Sumoylation, DNA, SUMO, Replication Protein A, Animals, Humans, Rad51 Recombinase, RPA, Repair, DNA Damage
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