Predicted expansion of the claudin multigene family
Copyright policy )Predicted expansion of the claudin multigene family
Claudins (Cldn) are essential membrane proteins of tight junctions (TJs), which form the paracellular permselective barrier. They are produced by a multi-gene family of 24 reported members in mouse and human. Based on a comprehensive search combined with phylogenetic analyses, we identified three novel claudins (claudin-25, -26, and -27). Quantitative RT-PCR revealed that the three novel claudins were expressed in a tissue- and/or developmental stage-dependent manner. Claudins-25 and -26, but not claudin-27, were immunofluorescently localized to TJs when exogenously expressed in cultured MDCK and Eph epithelial cell lines. These findings expand the claudin family to include at least 27 members.
- Osaka University Japan
- Niigata University Japan
- Hokkaido Bunkyo University Japan
- Hokkaido University Japan
- Kyoto University Japan
PSI-BLAST, Epithelial cells, Protein Structure, Secondary, Cell Line, Tight Junctions, Mice, Dogs, Animals, Humans, Protein Isoforms, Amino Acid Sequence, RNA, Messenger, Databases, Protein, Tight junction, Conserved Sequence, Phylogeny, Gene Library, Cell adhesion, Gene Expression Regulation, Developmental, Epithelial Cells, Paracellular barrier, Recombinant Proteins, Claudin, Organ Specificity, Claudins, Sequence Alignment
PSI-BLAST, Epithelial cells, Protein Structure, Secondary, Cell Line, Tight Junctions, Mice, Dogs, Animals, Humans, Protein Isoforms, Amino Acid Sequence, RNA, Messenger, Databases, Protein, Tight junction, Conserved Sequence, Phylogeny, Gene Library, Cell adhesion, Gene Expression Regulation, Developmental, Epithelial Cells, Paracellular barrier, Recombinant Proteins, Claudin, Organ Specificity, Claudins, Sequence Alignment
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