Collagen XVIII and corneal reinnervation following keratectomy
Copyright policy )Collagen XVIII and corneal reinnervation following keratectomy
The significance of collagen XVIII in the regulation of corneal reinnervation remains largely unknown. We used whole‐mount immunoconfocal microscopy to localize collagen XVIII to the nerve basement membrane of wild‐type (WT) mouse corneas. Transmission electron microscopy showed corneal nerve disorganization in collagen XVIII knockout mice (col18a1−/−). Antibody 2H3‐specific neurofilament colocalized with collagens XVIII and IV and laminin‐2 in WT mouse corneas, but did not colocalize with collagen IV and laminin‐2 in col18a1−/− mouse corneas. Following keratectomy, col18a1−/− mice displayed decreased corneal neurite extension compared to WT mice. Our data indicate that collagen XVIII may play an important role in corneal reinnervation after wounding.
- Harvard University United States
- Smith-Kettlewell Eye Research Institute United States
- University of Illinois at Chicago United States
- Yonsei University Medical Library Korea (Republic of)
- Yonsei University Health System Korea (Republic of)
Collagen Type IV, extracellular matrix, 610, Inbred C57BL, Electron, Cornea, Mice, Microscopy, Electron, Transmission, 616, Peripheral Nerves/physiology*, Neurites, Transmission, Animals, Collagen Type XVIII/physiology*, Peripheral Nerves, Corneal Injuries*, Wound Healing*/genetics, collagen XVIII, Microscopy, Wound Healing, Collagen Type XVIII/genetics, Cornea/physiology, Extracellular matrix, Neurites/physiology, Mice, Mutant Strains, Collagen Type IV/genetics, Peripheral Nerves/ultrastructure, Collagen Type XVIII, Nerve Regeneration, Mutant Strains, Mice, Inbred C57BL, Peripheral Nerves/metabolism, Cornea/innervation*, Collagen Type IV/physiology, Collagen XVIII, Nerve Regeneration*/genetics, Neurites/metabolism, Corneal Injuries
Collagen Type IV, extracellular matrix, 610, Inbred C57BL, Electron, Cornea, Mice, Microscopy, Electron, Transmission, 616, Peripheral Nerves/physiology*, Neurites, Transmission, Animals, Collagen Type XVIII/physiology*, Peripheral Nerves, Corneal Injuries*, Wound Healing*/genetics, collagen XVIII, Microscopy, Wound Healing, Collagen Type XVIII/genetics, Cornea/physiology, Extracellular matrix, Neurites/physiology, Mice, Mutant Strains, Collagen Type IV/genetics, Peripheral Nerves/ultrastructure, Collagen Type XVIII, Nerve Regeneration, Mutant Strains, Mice, Inbred C57BL, Peripheral Nerves/metabolism, Cornea/innervation*, Collagen Type IV/physiology, Collagen XVIII, Nerve Regeneration*/genetics, Neurites/metabolism, Corneal Injuries
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