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FEBS Letters
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http://dx.doi.org/10.1016/j.fe...
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FEBS Letters
Article . 2007 . Peer-reviewed
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FEBS Letters
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https://dx.doi.org/10.1016/j.f...
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Oleic acid: An efficient inhibitor of glucosyltransferase

descriptionPublicationkeyboard_double_arrow_right Article 29 Sep 2007 English Publisher:WileyJournal:FEBS Letters, volume 581, pages 4,999-5,002 (issn: 0014-5793, eissn: 1873-3468, Copyright policy )
Authors: Won, Se-Ra; Hong, Mi-Jung; Kim, Yong-Mu; Li, Chun Ying; Kim, Jang-Won; Rhee, Hae-Ik;

doi: 10.1016/j.febslet.2007.09.045

pmid: 17910959

Oleic acid: An efficient inhibitor of glucosyltransferase

Abstract

Among the extracts from 420 kinds of herbs, Prunus salicina, showing the highest glucosyltransferase inhibition activity, was purified and designated GTI‐0163. Structural determination of GTI‐0163 revealed it to be an oleic acid‐based unsaturated fatty acid. GTI‐0163 was an uncompetitive inhibitor of GTase. Among the unsaturated fatty acids, oleic acid showed a significantly higher GTase inhibitory activity than the saturated fatty acids or the ester form of oleic acid. These results strongly suggested that both the number of double bonds and the existence of free carboxyl groups of fatty acids play an important role in GTase inhibitory activity.

Related Organizations
Keywords

Prunus salicina, Glucosyltransferases, Plant Extracts, Dental caries, Prunus, Enzyme Inhibitors, GTase inhibitor, Oleic acid, Oleic Acid

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    popularity
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    influence
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
43
Top 10%
Top 10%
Top 10%
bronze