Phosphorylation of the liver X receptors
Copyright policy )Phosphorylation of the liver X receptors
The liver X receptors (LXRs) function as nutritional sensors for cholesterol and have important roles in lipid metabolism, glucose homeostasis, and inflammation. We provide the first evidence that LXRs are phosphorylated proteins. Mutational analysis and metabolic labeling indicate LXRα is phosphorylated on serine 198 in the hinge region. This is a consensus target for the MAPK family. A phosphorylation‐deficient mutant, LXRα S198A, remains nuclear and responds to ligands like the wild‐type protein. The biological significance of LXR phosphorylation remains to be elucidated but could provide a novel mechanism for the regulation of LXR signaling pathways and cellular metabolism.
- University of California Los Angeles United States
- University of California at Los Angeles United States
- University of California, Los Angeles
- University of California, Los Angeles United States
- Howard Hughes Medical Institute United States
DNA Mutational Analysis, Receptors, Cytoplasmic and Nuclear, Orphan Nuclear Receptors, Cell Line, DNA-Binding Proteins, Mice, Genes, Reporter, Serine, Cholesterol metabolism, Animals, Humans, Liver X receptor, Phosphorylation, Promoter Regions, Genetic, Liver X Receptors, Signal Transduction
DNA Mutational Analysis, Receptors, Cytoplasmic and Nuclear, Orphan Nuclear Receptors, Cell Line, DNA-Binding Proteins, Mice, Genes, Reporter, Serine, Cholesterol metabolism, Animals, Humans, Liver X receptor, Phosphorylation, Promoter Regions, Genetic, Liver X Receptors, Signal Transduction
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