Biology of vascular endothelial growth factors
Copyright policy )Biology of vascular endothelial growth factors
Angiogenesis is the process by which new blood vessels are formed from existing vessels. The vascular endothelial growth factors (VEGFs) are considered as key molecules in the process of angiogenesis. The VEGF family currently includes VEGF‐A, ‐B, ‐C, ‐D, ‐E, ‐F and placenta growth factor (PlGF), that bind in a distinct pattern to three structurally related receptor tyrosine kinases, denoted VEGF receptor‐1, ‐2, and ‐3. VEGF‐C and VEGF‐D also play a crucial role in the process of lymphangiogenesis. Here, we review the biology of VEGFs and evaluate their role in pathological angiogenesis and lymphangiogenesis.
- Kuopio University Hospital Finland
- University of Eastern Finland Finland
Vascular Endothelial Growth Factor A, Wound Healing, Neovascularization, Pathologic, Diseases, VEGF, Signaling, Arthritis, Rheumatoid, Neoplasms, Humans, Angiogenesis, Lymphedema, Lymphatic Vessels
Vascular Endothelial Growth Factor A, Wound Healing, Neovascularization, Pathologic, Diseases, VEGF, Signaling, Arthritis, Rheumatoid, Neoplasms, Humans, Angiogenesis, Lymphedema, Lymphatic Vessels
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