Coenzyme Q is irreplaceable by demethoxy‐coenzyme Q in plasma membrane ofCaenorhabditis elegans

descriptionPublicationkeyboard_double_arrow_right Article 20 Feb 2006 Spain English Publisher:WileyJournal:FEBS Letters, volume 580, pages 1,740-1,746 (issn: 0014-5793, eissn: 1873-3468,

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Authors: Arroyo, Antonio; Santos-Ocaña, Carlos; Ruiz-Ferrer, Macarena; Padilla, Sergio; Gavilán, Angela; Rodríguez-Aguilera, Juan Carlos; Navas, Plácido;

doi: 10.1016/j.febslet.2006.02.025

pmid: 16504181

handle: 10261/40674

Coenzyme Q is irreplaceable by demethoxy‐coenzyme Q in plasma membrane ofCaenorhabditis elegans

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Abstract

A procedure was developed to isolate fractions enriched in plasma membrane fromCaenorhabditis elegans. Coenzyme Q9(Q9) was found in plasma membrane isolated from either wild‐type or long‐livedqm30andqm51 clk‐1mutant strains ofCaenorhabditis elegans, along with dietary coenzyme Q8(Q8) and the biosynthetic intermediate demethoxy‐Q9(DMQ9). NADH was able to reduce both Q8and Q9, but not DMQ9. Our results indicate that DMQ9cannot achieve the same redox role of Q9in plasma membrane, suggesting that proportion of all these Q isoforms in plasma membrane must be an important factor in establishing theclk‐1mutant phenotype.

Country

Spain

Related Organizations

Spanish National Research Council
Spain
Pablo de Olavide University
Spain
Centro Andaluz de Biología del Desarrollo
Spain

Keywords

Demethoxy-coenzyme Q, Ubiquinone, Cell Membrane, Coenzyme Q, NAD, clk-1 mutant phenotype, Animals, Coenzyme Q10, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Oxidation-Reduction, Plasma membrane

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