A novel toxin from the venom of the scorpion Tityus trivittatus, is the first member of a new α‐KTX subfamily
Copyright policy )A novel toxin from the venom of the scorpion Tityus trivittatus, is the first member of a new α‐KTX subfamily
The first example of a new sub‐family of toxins (α‐KTx20.1) from the scorpion Tityus trivittatus was purified, sequenced and characterized physiologically. It has 29 amino acid residues, three disulfide bridges assumed to adopt the cysteine‐stabilized α/β scaffold with a pI value of 8.98. The sequence identities with all the other known α‐KTx are less than 40%. Its effects were verified using seven different cloned K+ channels (vertebrate Kv1.1–1.5, Shaker IR and hERG) expressed in Xenopus leavis oocytes. The toxin‐induced effects show large differences among the different K+ channels and a preference towards Kv1.3 (EC50 = 7.9 ± 1.4 nM).
- KU Leuven Belgium
- National Autonomous University of Mexico Mexico
- Katholieke Universiteit Leuven Belgium
- Universidad Del Valle De Cuernavaca Mexico
Voltage-gated K+ channels, Potassium Channels, Molecular Sequence Data, α-KTx20.1, Scorpion Venoms, Scorpions, Tityus trivittatus, Potassium Channel Blockers, Animals, Amino Acid Sequence, Sequence Alignment
Voltage-gated K+ channels, Potassium Channels, Molecular Sequence Data, α-KTx20.1, Scorpion Venoms, Scorpions, Tityus trivittatus, Potassium Channel Blockers, Animals, Amino Acid Sequence, Sequence Alignment
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