Transient impairment of the adaptive response to fasting in FXR‐deficient mice
Copyright policy )Transient impairment of the adaptive response to fasting in FXR‐deficient mice
The farnesoid X receptor (FXR) has been suggested to play a role in gluconeogenesis. To determine whether FXR modulates the response to fasting in vivo, FXR‐deficient (FXR−/−) and wild‐type mice were submitted to fasting for 48 h. Our results demonstrate that FXR modulates the kinetics of alterations of glucose homeostasis during fasting, with FXR−/− mice displaying an early, accelerated hypoglycaemia response. Basal hepatic glucose production rate was lower in FXR−/− mice, together with a decrease in hepatic glycogen content. Moreover, hepatic PEPCK gene expression was transiently lower in FXR−/−mice after 6 h of fasting and was decreased in FXR−/−hepatocytes. FXR therefore plays an unexpected role in the control of fuel availability upon fasting.
- National Institutes of Health United States
- Amsterdam UMC Netherlands
- National Institute of Health Pakistan
- Pasteur Institute of Lille France
- University Medical Center Groningen Netherlands
EXPRESSION, HOMEOSTASIS, LIVER, fasting, INHIBITION, Receptors, Cytoplasmic and Nuclear, METABOLISM, PEPCK, PHOSPHOENOLPYRUVATE CARBOXYKINASE, Mice, Farnesoid X receptor, Animals, Homeostasis, CYCLE, DNA Primers, Mice, Knockout, BILE-ACIDS, Base Sequence, Reverse Transcriptase Polymerase Chain Reaction, Gluconeogenesis, Fasting, GLUCONEOGENESIS, Adaptation, Physiological, Liver Glycogen, DNA-Binding Proteins, gluconeogenesis, Liver, Female, farnesoid X receptor, FARNESOID-X-RECEPTOR, Phosphoenolpyruvate Carboxykinase (ATP), Transcription Factors
EXPRESSION, HOMEOSTASIS, LIVER, fasting, INHIBITION, Receptors, Cytoplasmic and Nuclear, METABOLISM, PEPCK, PHOSPHOENOLPYRUVATE CARBOXYKINASE, Mice, Farnesoid X receptor, Animals, Homeostasis, CYCLE, DNA Primers, Mice, Knockout, BILE-ACIDS, Base Sequence, Reverse Transcriptase Polymerase Chain Reaction, Gluconeogenesis, Fasting, GLUCONEOGENESIS, Adaptation, Physiological, Liver Glycogen, DNA-Binding Proteins, gluconeogenesis, Liver, Female, farnesoid X receptor, FARNESOID-X-RECEPTOR, Phosphoenolpyruvate Carboxykinase (ATP), Transcription Factors
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