Capped acyclic permutants of the circular protein kalata B1
Copyright policy )Capped acyclic permutants of the circular protein kalata B1
The cyclotides are a family of head‐to‐tail cyclized peptides that display exceptionally high stability and a range of biological activities. Acyclic permutants that contain a break in the circular backbone have been reported to be devoid of the haemolytic activity of the prototypic cyclotide kalata B1, but the potential role of the charges at the introduced termini in this loss of membraneolytic activity has not been fully determined. In this study, acyclic permutants of kalata B1 with capped N‐ and C‐termini were synthesized and found to adopt a native fold. These variants were observed to cause no measurable lysis of erythrocytes, strengthening the connection between backbone cyclization and haemolytic activity.
- University of Queensland Australia
- University of Quensland Australia
- University of Queensland Australia
- University of Queensland Australia
- University of Queensland Australia
Biochemistry & Molecular Biology, Protein Folding, 250302 Biological and Medical Chemistry, Erythrocytes, Protein Conformation, Molecular Sequence Data, Biophysics, Plant Cyclotides, Molecular Conformation, Cyclotides, Rubiaceae, Hemolysis, Cyclic Peptide, C1, Beta-sheet, Amidation, Animals, Amino Acid Sequence, Cysteine, Disulfides, Nuclear Magnetic Resonance, Biomolecular, Plant Proteins, Chromatography, Sheep, Dose-Response Relationship, Drug, 780105 Biological sciences, Structural Motif, Polypeptides, Haemolysis, Proteins, Acetylation, Cell Biology, 540, Cyclotide, Cystine-knot, Mutation, Cyclic peptide, Peptides
Biochemistry & Molecular Biology, Protein Folding, 250302 Biological and Medical Chemistry, Erythrocytes, Protein Conformation, Molecular Sequence Data, Biophysics, Plant Cyclotides, Molecular Conformation, Cyclotides, Rubiaceae, Hemolysis, Cyclic Peptide, C1, Beta-sheet, Amidation, Animals, Amino Acid Sequence, Cysteine, Disulfides, Nuclear Magnetic Resonance, Biomolecular, Plant Proteins, Chromatography, Sheep, Dose-Response Relationship, Drug, 780105 Biological sciences, Structural Motif, Polypeptides, Haemolysis, Proteins, Acetylation, Cell Biology, 540, Cyclotide, Cystine-knot, Mutation, Cyclic peptide, Peptides
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