The chilean superfruit black-berry Aristotelia chilensis (Elaeocarpaceae), Maqui as mediator in inflammation-associated disorders
Copyright policy )The chilean superfruit black-berry Aristotelia chilensis (Elaeocarpaceae), Maqui as mediator in inflammation-associated disorders
The effects of phytochemicals occurred in fractions and extracts of fruits of "Maqui-berry" (Aristotelia chilensis), on the expression of cyclooxygenase-2 (COX-2), inducible-nitric oxide synthases (iNOS) and the production of proinflammatory mediators were investigated in lipopolysaccharide (LPS)-activated murine macrophage RAW-264 cells, as well as their antioxidant activities. The MeOH extract (A), acetone/methanol extract (B), fractions F3, F4, subfractions (SF4-SF6, SF7, SF8-SF10, SF11-SF15, SF16-SF20), quercetin, gallic acid, luteolin, myricetin, mixtures M1, M2 and M3 exhibited potent anti-inflammatory and antioxidant activities. The results indicated that anthocyanins, flavonoids and its mixtures suppressed the LPS induced production of nitric oxide (NO), through the down-regulation of iNOS and COX-2 protein expressions and showed a potent antioxidant activity against SOD, ABTS, TBARS, ORAC, FRAP and DCFH. The inhibition of enzymes and NO production by selected fractions and compounds was dose-dependent with significant effects seen at concentration as low as 1.0-50.0 (ppm) and 5.0-10.0 μM, for samples (extracts, fractions, subfractions and mixtures) and pure compounds, respectively. Thus, the phenolics (anthocyanins, flavonoids, and organic acids) as the fractions and mixtures may provide a potential therapeutic approach for inflammation associated disorders and therefore might be used as antagonizing agents to ameliorate the effects of oxidative stress.
- University of California, Berkeley United States
- University of Bío-Bío Chile
- National Autonomous University of Mexico Mexico
Inflammation, Oxygen Radical Absorbance Capacity, Plant Extracts, Elaeocarpaceae, Iron, Biphenyl Compounds, Brain, Nitric Oxide Synthase Type II, Polyphenols, Thiobarbituric Acid Reactive Substances, Rats, Mice, RAW 264.7 Cells, Picrates, Cyclooxygenase 2, Fruit, Animals, Lipid Peroxidation, Oxidation-Reduction
Inflammation, Oxygen Radical Absorbance Capacity, Plant Extracts, Elaeocarpaceae, Iron, Biphenyl Compounds, Brain, Nitric Oxide Synthase Type II, Polyphenols, Thiobarbituric Acid Reactive Substances, Rats, Mice, RAW 264.7 Cells, Picrates, Cyclooxygenase 2, Fruit, Animals, Lipid Peroxidation, Oxidation-Reduction
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