This report presented a review of the process of wound healing as well as influencing factors in the process such as wound healing agents. A greater understanding of the alterations in diabetes mellitus allows selection of the optimal wound healing agents to provide a more optimistic approach to wound closure for this large population of diabetics. We have reviewed some of the most common products use adjuncts to the healing process. With newer innovation such as the use of negative pressure dressings and HBO therapy, the treatment of diabetic wound continues to improve. With the increased number of healing agents, it is important to consider the kind of wound and the conditions present when selecting one healing agent over another.