The Variable Infiltration Capacity (VIC) hydrologic and river routing model simulates the water and energy fluxes that occur near the land surface and provides useful information regarding the quantity and timing of available water within a watershed system. However, despite its popularity, wider adoption is hampered by the considerable effort required to prepare model inputs and calibrate the model parameters. This study presents a user-friendly software package, named VIC-Automated Setup Toolkit (VIC-ASSIST), accessible through an intuitive MATLAB graphical user interface. VIC-ASSIST enables users to navigate the model building process through prompts and automation, with the intention to promote the use of the model for practical, educational, and research purposes. The automated processes include watershed delineation, climate and geographical input set-up, model parameter calibration, sensitivity analysis, and graphical output generation. We demonstrate the package's utilities in various case studies. We introduce VIC-Automated Setup Toolkit (VIC-ASSIST).VIC-ASSIST framed within a MATLAB GUI aids building and calibrating the VIC model.VIC-ASSIST helps users navigate the model building processes through automation.We demonstrate the package's utilities in various case studies.