AbstractThe purpose of this study is to explore the possibility to mimic, in silico, biological experiments. From the formulation of a biological model using a formal calculus, the corresponding stochastic simulations are statistically compared with measured experimental data in terms of its qualitative behavior. The result of this comparison is indicative of the possible integration of laboratory experiments with computational simulations. The biological case study concerns calcium as a second messenger which transmit external refers to recent experiments of calcium responses to endosymbiotic Arbuscular Mycorrhizal (AM) fungi in the host plant root epidermis. The employed formal tool is the Calculus of Wrapped Compartments (CWC) which combines the simplicity of notation of rewrite systems with the advantage of compositionality.