AbstractThe synchronous hypothesis arose in the late Eighties as a conceptual framework for the computer-aided design of embedded systems. Along with this framework, the issue of desynchronization was simultaneously raised as the major topic of mapping the ideal communication and computation model of synchrony on realistic and distributed computer architectures.The aim of the present article is to survey the development of this topics in the particular yet promising model of one of the prominent environments that were build along these principles: Signal and its polychronous (synchronous multi-clocked) model of computation, before to give some hints and ideas about ongoing research addressing this issue.