This research aims to predict the maximum shear capacity of Composite Steel Plate Shear Walls (CSPSWs) through nonlinear Finite Element (NLFE) analyses and Response Surface Method (RSM). The variables are concrete thickness and compressive strength, steel infill plate thickness, and yield stress. A parametric study was performed on CSPSW comprising a concrete layer on one side of the infill plate and the corresponding models having the concrete layer between the two plates. The results show that RSM is a reliable practice for precisely predicting the maximum shear capacity of the studied models. Furthermore, comparing the RSM results with those acquired by Linear Regression (LR) indicated that RSM is more accurate than LR. Moreover, in the models with the internal concrete layer, the concrete contributed more to the shear capacity of the specimens, and this difference expands with an increase in the thickness of the concrete layer.