Balloon-framed cross-laminated timber (CLT) construction has a number of advantages when compared to platform-type construction; however, many international standards only include provisions for the latter as there is little research reported on the seismic performance of the former. In this paper, a seismic fragility assessment of a 4-storey balloon-framed CLT building in Vancouver, Canada, is presented. This structure is the first in North America that adopts a self-centering friction-based technology for the hold-downs (HDs). The seismic performance of the building was assessed by performing incremental dynamic analysis (IDA) on a three-dimensional finite element model using Cascadia Subduction Zone ground motions, and compared to a second building model with conventional dowel-type HDs. The analyses at the design intensity level showed that the self-centering building had an average maximum inter-story drift ratio of 0.67%, well below the 2.5% drift limit specified in the National Building Code of Canada. Based on the IDA and taking into account uncertainties, the building had a collapse margin ratio of 2.96 and a 5.2% probability of collapse at the design level. Compared to the conventional HDs, the friction-based HDs did not improve the building's collapse capacity, but reduced the building drift by more than 20% at lower damage states, demonstrating the effectiveness of designing balloon-framed CLT structures with a resilient self-centering HDs in high seismic zones. © 2023 Elsevier Ltd