
pmid: 16887320
This study was undertaken to investigate whether total number of nodes (pNtot) removed, negative nodes removed (pNneg), and ratio of positive nodes to total nodes removed (pNratio) are predictors of survival in node positive patients.The records of 801 consecutive invasive breast cancer patients with T1-3 tumour and positive axillary lymph node who underwent modified radical mastectomy in our hospital were reviewed. pNtot and pNneg were categorized, and pNratio was computed. The influence of these probable prognostic factors on survival was investigated. Survival curves were generated by Kaplan-Meier method and log-rank test was used for comparisons. Multivariate analyses were performed by Cox proportional hazard model.Median pNtot, and pNneg are 19 (range 5-54), and 13 (range 0-53), respectively. pNtot>15, and pNneg>15 were independently associated with reduced hazard ratios (HRs) of 0.62 (CI 0.48-0.79), and 0.68 (CI 0.52-0.89), respectively. The highest ratio (>0.25) of pNratio is associated with the highest hazard ratio for death (HR 3.8, CI 2.74-5.50) compared to the lowest ratio for death (15) or negative nodes (>15) are associated with increased survival.
Adult, Carcinoma, Ductal, Breast, Breast Neoplasms, Middle Aged, Prognosis, Survival Rate, Lymphatic Metastasis, Axilla, Humans, Lymph Node Excision, Female, Mastectomy, Radical, Aged
Adult, Carcinoma, Ductal, Breast, Breast Neoplasms, Middle Aged, Prognosis, Survival Rate, Lymphatic Metastasis, Axilla, Humans, Lymph Node Excision, Female, Mastectomy, Radical, Aged
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